Sung Min Yang

Human brain organoids record the passage of time over multiple years in culture

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

Cell-type specific developmental defects in PTEN-mutant cortical organoids converge on abnormal circuit activity

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

Neuron-class specific responses govern adaptive remodeling of myelination in the neocortex

The paper investigates how different neuron types in the mouse visual cortex adapt myelination in response to sensory experience, finding that only inhibitory interneurons undergo experience-dependent myelin remodeling.

Differential coupling of adult-born granule cells to parvalbumin and somatostatin interneurons

This study investigates the connectivity dynamics between adult-born granule cells and inhibitory interneurons in the hippocampus, revealing distinct developmental patterns and functional roles.