The cohesin ring uses its hinge to organize DNA using non-topological as well as topological mechanisms
Madhusudhan Srinivasan, Johanna C. Scheinost, Naomi J Petela, Thomas G. Gligoris, Maria F. Wissler, Sugako Ogushi, James Collier, Menelaos Voulgaris, Alexander Kurze, Kok‐Lung Chan, Bin Hu, Vincenzo Costanzo, Kim Nasmyth
The paper investigates how cohesin organizes DNA through both topological and non-topological mechanisms, showing that hinge domain mutations affect DNA entrapment and loading.
Cell · May 1, 2018Peer-reviewedMolecular Biology