This study shows Scc2/4 maintains cohesin on chromosomes during G1 by blocking a Wapl-independent release mechanism, but is unnecessary during S phase for establishing cohesion.

DOI 10.1101/513960

experimental assay

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Molecular BiologyCellPeer-reviewedMay 1, 2018

The cohesin ring uses its hinge to organize DNA using non-topological as well as topological mechanisms

Madhusudhan Srinivasan, Johanna C. Scheinost, Naomi J Petela…·Kim Nasmyth

The paper investigates how cohesin organizes DNA through both topological and non-topological mechanisms, showing that hinge domain mutations affect DNA entrapment and loading.

150 citationstop 2%

experimental assay

𝕏 PostBluesky

Cell BiologybioRxivPreprintOct 19, 2017

Multiple interactions between Scc1 and Scc2 activate cohesin’s DNA dependent ATPase and replace Pds5 during loading

Naomi J Petela, Thomas G Gligoris, Jean Metson…·Kim A Nasmyth

The paper investigates how Scc1 and Scc2 interactions regulate cohesin's ATPase activity and displacement of Pds5 during loading.

DOI 10.1101/205914

experimental assaycell signaling & trafficking

𝕏 PostBluesky