Samuel H. Crossman

Observing concurrent subcellular dynamics in large living tissues

This paper introduces Airy beam light sheet microscopy to image subcellular dynamics in large tissues with high spatial and temporal resolution across multiple organisms and biological processes.

Ca2+-mediated protein citrullination regulates proliferation in the regenerating and malignant CNS

This paper identifies Ca2+-mediated protein citrullination as a regulator of neural stem cell proliferation in CNS regeneration and cancer, showing PAD inhibitors suppress medulloblastoma growth.

Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease

This paper demonstrates optogenetic delivery of trophic signals using light-activated receptors to suppress disease phenotypes in Parkinson's disease models.

Lessons in genome engineering: opportunities, tools and pitfalls

The paper describes CRISPR/Cas9-based tools for creating genetic modifications in Drosophila and highlights challenges and solutions in genome engineering.

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development

The paper shows that EGFR signaling coordinates patterning with cell survival in Drosophila epidermis by regulating pro-apoptotic gene expression based on ligand availability.