Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
Valeria Ramaglia, Mohit Dubey, Alfonso Mauro Malpede, Naomi Petersen, Sharon I. de Vries, Shanzeh M. Ahmed, Dennis S. W. Lee, Geert J. Schenk, Stefan Michael Gold, Inge Huitinga, Jennifer L. Gommerman, Jeroen J.G. Geurts, Maarten H. P. Kole
The paper investigates complement system involvement in synapse loss in MS hippocampus, finding C1q deposits linked to inhibitory synapse loss and impaired memory.
Acta Neuropathologica · Jun 25, 2021Peer-reviewedNeuroscience