T6SS mutants exploit itaconate to support infection of phagocytes
Ayesha Zainab Beg, Blanche L. Fields, Ying-Tsun Chen, Tania Wong Fok Lung, Griffin Gowdy, Absar Talat, Asad U. Khan, Shivang S. Shah, Ian A. Lewis, Sebastián A. Riquelme, Alice Prince
This study shows that Pseudomonas aeruginosa mutants lacking the H3-T6SS exploit itaconate to persist in phagocytes, enhancing their ability to cause chronic lung infections.
bioRxiv · Mar 19, 2026 · PreprintImmunology