Author

Sebastián A. Riquelme

Columbia UniversityORCID 0000-0002-8375-4320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ayesha Zainab BegiD· 2 shared Ian A. LewisiD· 2 shared Shivang S. ShahiD· 2 shared Tania Wong Fok LungiD· 2 shared Ying-Tsun CheniD· 2 shared Abderrahman HachaniiD· 1 shared Absar TalatiD· 1 shared Alice Prince· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Ayesha Zainab BegORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

T6SS mutants exploit itaconate to support infection of phagocytes

Ayesha Zainab Beg, Blanche L. Fields, Ying-Tsun Chen, Tania Wong Fok Lung, Griffin Gowdy, Absar Talat, Asad U. Khan, Shivang S. Shah, Ian A. Lewis, Sebastián A. Riquelme, Alice Prince

This study shows that Pseudomonas aeruginosa mutants lacking the H3-T6SS exploit itaconate to persist in phagocytes, enhancing their ability to cause chronic lung infections.

bioRxiv · Mar 19, 2026 · PreprintImmunology

Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia

Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios-Delgado, Henning Henschel, N. Tyagi, Françios A.B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha Hara Sridhar, Marija Drikic, Colleen M. Bianco, , Tania Wong Fok Lung

This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.

Nature Communications · Aug 1, 2025Peer-reviewedMicrobiology