Author
Purdue University West LafayetteORCID 0000-0002-1357-2919Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Abdelrahman M. Salem, Wenzhu Qi, Jean-Christophe Rochet, Kevin J. Webb
This paper introduces a FLIM-FRET method to quantify membrane-proximal alpha-synuclein aggregation in neurons by estimating per-cell lifetimes and mixture fractions using a hierarchical EM algorithm.
Paula-Marie E. Ivey, Magaly Guzman Sosa, Abdelrahman M. Salem…·Kevin John Webb
This study uses fluorescence lifetime imaging to track alpha-synuclein aggregation in neurons, revealing that seeds disassemble before escaping endolysosomes and triggering cytosolic aggregation.
Paula-Marie E. Ivey, Abdelrahman M. Salem, Sehong Min…·Kevin John Webb
The paper develops a FLIM method to study membrane-induced alpha-synuclein aggregation in neurons, providing insights into Parkinson's disease mechanisms.