Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
Eric D. Queathem, Zahra Moazzami, David B. Stagg, Alisa B. Nelson, Kyle Fulghum, Abdirahman Hayir, Alisha Seay, Jacob R. Gillingham, D. André d’Avignon, Xianlin Han, Hai‐Bin Ruan, Peter A. Crawford, Patrycja Puchalska
The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.
Science Advances · Jan 29, 2025Peer-reviewedBiochemistry