Author

Jacob R. Gillingham

University of MinnesotaORCID 0000-0002-6717-9960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Abdirahman Hayir· 2 shared Alisa B. NelsoniD· 2 shared D. André d’Avignon· 2 shared David B. StaggiD· 2 shared Eric D. QueathemiD· 2 shared Kyle FulghumiD· 2 shared Patrycja PuchalskaiD· 2 shared Peter A. CrawfordiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBiochemistry

Abdirahman Hayir

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate

Eric D. Queathem, David B. Stagg, Alisa B. Nelson, Alec Chaves, Scott B. Crown, Kyle Fulghum, D. André d’Avignon, Justin R. Ryder, Patrick J. Bolan, Abdirahman Hayir, Jacob R. Gillingham, Shannon Jannatpour, Ferrol I. Rome, Ashley S. Williams, Deborah M. Muoio, , Peter A. Crawford

Journal of Clinical Investigation · Apr 24, 2025Peer-reviewedBiochemistry

Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation

Eric D. Queathem, Zahra Moazzami, David B. Stagg, Alisa B. Nelson, Kyle Fulghum, Abdirahman Hayir, Alisha Seay, Jacob R. Gillingham, D. André d’Avignon, Xianlin Han, Hai‐Bin Ruan, Peter A. Crawford, Patrycja Puchalska

The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.

Science Advances · Jan 29, 2025Peer-reviewedBiochemistry

kinact/KI Value Determination for Penicillin-Binding Proteins in Live Cells

Joshua D. Shirley, Jacob R. Gillingham, Kelsie M. Nauta, Shivani Diwakar, Erin E. Carlson

The paper develops a whole-cell assay to measure kinact/KI values for PBPs in Streptococcus pneumoniae, showing results consistent with in vitro data and supporting its validity as an in vivo method.

ACS Infectious Diseases · Dec 4, 2024Peer-reviewedBiochemistry