Patrycja Puchalska

Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

Diet-Dependent Cognitive Benefits of Exogenous Ketone Body Precursor, (R,S)-1,3,-Butanediol, in a Mouse Model of Tauopathy

This study shows that (R,S)-1,3-butanediol improves memory in female tauopathy mice on chow but not on high-fat diets or after long-term use, highlighting sex and diet-dependent cognitive benefits.

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

Ketone body driven lipid remodeling supports thermogenic adaptation to fasting

The paper shows that ketone bodies support thermogenic adaptation in BAT during fasting by promoting lipid remodeling and thermogenesis.

Reduced Liver Mitochondrial Energy Metabolism Impairs Food Intake Regulation Following Gastric Preloads and Fasting

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment

This study uses multiomic analysis to investigate metabolic interactions between colorectal cancer cells and hepatocytes in liver metastasis, revealing metabolic shifts and potential therapeutic targets.

Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation

The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.

ATP-Gated Potassium Channels Contribute to Ketogenic Diet-Mediated Analgesia in Mice.

This study shows that a ketogenic diet reduces pain in mice through ketone oxidation and activation of ATP-gated potassium channels.

Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.

This study shows that ketone metabolism is essential for the development and function of the somatosensory nervous system, with loss of ketolysis causing myelination deficits and proprioceptive impairments.

Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.