Protective ApoE variants support neuronal function by extracting peroxidated lipids
Isha Ralhan, Alison D. Do, Ju-Young Bae, Femke M. Feringa, Wendy Cai, Jinlan Chang, Kennedi Chik, Nathanael Y.J. Lee, Christopher J. Gerry, Rik van der Kant, Jesse Jackson, Emily L. Ricq, Maria S. Ioannou
The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.
Neuron · Dec 2, 2025Peer-reviewedNeuroscience