Author

Nathanael Y.J. Lee

University of AlbertaORCID 0000-0003-2831-4100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Jinlan ChangiD· 3 shared Maria S. IoannouiD· 3 shared Isha RalhaniD· 2 shared Jesse JacksoniD· 2 shared Ju-Young Bae· 2 shared Kennedi Chik· 2 shared Wendy Cai· 2 shared Alison D. Do· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jinlan ChangORCID

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Author profile →

3 papers

Recent·Most cited

ApoE4 impairs astrocyte lipid droplet formation via endolysosomal dysfunction

Isha Ralhan, Ju-Young Bae, Nathanael Y.J. Lee, Wendy Cai, Jinlan Chang, Suha Jarad, Hongmei Gu, Dawei Zhang, Maria S. Ioannou

This study shows ApoE4 impairs astrocyte lipid droplet formation by disrupting endolysosomal function and demonstrates that PCSK9 can restore lipid droplet formation by preventing ApoE4 internalization.

bioRxiv · Sep 4, 2026 · PreprintNeuroscience

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease

Julie Jacquemyn, Brian A. Marriott, Jinlan Chang, Ehlam Iftikhar, Kennedi Chik, Nathanael Y.J. Lee, Luis Fernando Rubio-Atonal, Ceili Green, Jeremy Wong, Claudia Acevedo-Morantes, Carol X.‐Q. Chen, Michaël Nicouleau, Zhipeng You, Éric Deneault, Narges Abdian, , Maria S. Ioannou

This study shows that glucosylceramide-induced ectosomes transmit pathogenic α-synuclein between neurons in Parkinson's disease.

Nature Cell Biology · Feb 12, 2026Peer-reviewedCell Biology

Protective ApoE variants support neuronal function by extracting peroxidated lipids

Isha Ralhan, Alison D. Do, Ju-Young Bae, Femke M. Feringa, Wendy Cai, Jinlan Chang, Kennedi Chik, Nathanael Y.J. Lee, Christopher J. Gerry, Rik van der Kant, Jesse Jackson, Emily L. Ricq, Maria S. Ioannou

The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.

Neuron · Dec 2, 2025Peer-reviewedNeuroscience