Katherine R. Calvo

HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc- Driven Small Cell Lung Cancer

This study shows that HDAC inhibition with entinostat enhances immunotherapy response in SCLC by reprogramming tumor immunology and neuroendocrine status.

Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML

CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque

This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.