Author

Selami Demirci

National Institutes of HealthORCID 0000-0002-6174-1609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

John F. TisdaleiD· 2 shared Allen E. Krouse· 1 shared Archana Verma· 1 shared Aylin C. Bonifacino· 1 shared Christian BrendeliD· 1 shared Chuanfeng WuiD· 1 shared Cynthia E. DunbariD· 1 shared Daniel E. BaueriD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

John F. TisdaleORCID

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2 papers

Recent·Most cited

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

Cell stem cell · Dec 12, 2024Peer-reviewedGenetics

Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque

Diego A. Espinoza, Xing Fan, Di Yang, Stefan Cordes, Lauren L. Truitt, Katherine R. Calvo, Idalia M. Yabe, Selami Demirci, Kristin J. Hope, So Gun Hong, Allen E. Krouse, Mark E. Metzger, Aylin C. Bonifacino, Rong Lu, Naoya Uchida, , Cynthia E. Dunbar

This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.

Molecular Therapy · Apr 9, 2019Peer-reviewedMolecular Biology