Ishay Ben-Zion

This paper introduces a CRISPRi-based PROSPECT platform for drug discovery in M. abscessus, identifying new compound targets and revealing unexpected susceptibility to isoniazid.

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

The paper identifies a dimmer-switch gene regulation mechanism in yeast by decoupling transcription factor expression and activity.

The paper shows that intercellular positive feedback loops stabilize microbial cooperation by reducing the need for population structure, using synthetic biology experiments with Bacillus subtilis.