Author

Pegah Ghiabi

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Aiping DongiD· 3 shared Albina Bolotokova· 3 shared Elisa GibsoniD· 3 shared Levon HalabelianiD· 3 shared Peter J. BrowniD· 3 shared Rachel HardingiD· 3 shared Suzanne Z. AcklooiD· 3 shared A.M. EdwardsiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

Aiping DongORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, U Hang Chan, Hong Zeng, Conrad Veranso Simoben, Stuart R. Green, Madhushika Silva, Scott Houliston, Aiping Dong, Albina Bolotokova, Elisa Gibson, Maria Kutera, , Levon Halabelian

This study introduces E-ASMS, a method to detect weak binders and assess enantioselectivity, identifying 16 binders across 12 human protein targets with confirmed binding mechanisms.

Nature Communications · Dec 17, 2025Peer-reviewedPharmacology & Toxicology

Identification of Inhibitors of Chikungunya virus nsP2 ATPase

Hernán A. Navarro, John E. Scott, Ginger R. Smith, Pegah Ghiabi, Elisa Gibson, P. Loppnau, Rachel Harding, Mohammad Anwar Hossain, M. Bose, Kenneth H. Pearce, Eric M. Merten, Timothy Mark Willson, Peter J. Brown

The paper identifies inhibitors of Chikungunya virus nsP2 ATPase by screening compounds that reduce ATP hydrolysis.

bioRxiv · Dec 2, 2024 · PreprintBiochemistry

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

Fengling Li, Suzanne Z. Ackloo, C. H. Arrowsmith, Fuqiang Ban, Christopher Barden, Hartmut Beck, Jan Beránek, Francois Berenger, Albina Bolotokova, Guillaume Bret, Marko Breznik, Emanuele Carosati, Irene Chau, Yu Chen, Artem R Cherkasov, , Matthieu Schapira

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

Journal of Chemical Information and Modeling · Nov 5, 2024Peer-reviewedBiochemistry

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Shabbir Ahmad, Jin Bao Xu, Jianwen A. Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi, Aiping Dong, Paolo A. Centrella, Matthew Clark, Marie-Aude Guié, John P. Guilinger, Anthony D. Keefe, Ying Zhang, Thomas Cerruti, John W. Cuozzo, , Levon Halabelian

The paper identifies a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection and machine learning, leading to the discovery of covalent analogs and structural insights.

Journal of Medicinal Chemistry · Nov 23, 2023Peer-reviewedMolecular Biology