Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Kirandeep K. Deol, Cynthia A. Harris, Sydney J. Tomlinson, Colin J. Delaney, Amr Al-Farhan, Alyssa J. Mathiowetz, Cody E. Doubravsky, Derek A. Pratt, James A. Olzmann
This study identifies vitamin B2 metabolism as a regulator of FSP1 stability, which prevents ferroptosis by maintaining FSP1 function through FAD cofactor binding.
Nature Structural & Molecular Biology · Mar 1, 2026Peer-reviewedCell Biology