Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3
Gunjan Sharma, Martin E Gutierrez, Anthony E. Jones, S. S. Kapoor, Amit Kumar Jaiswal, Zachary T. Neeb, Amy Rios, Poornima Dorairaj, Michelle L. Thaxton, Tasha Lotus Lin, Tiffany M. Tran, Lyna E.S. Kabbani, Alexander J. Ritter, Georgia Scherer, Jacob P. Sorrentino, , Dinesh S. Rao
This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.
Cell Reports · Sep 27, 2025Peer-reviewedCancer Biology