Lysosome-dependent nutrient scavenging underliesstress adaptation during epithelial-to-mesenchymaltransition
Michal J. Nagiec, Paola M. Cavaliere, Friederike Dündar, Derrick M. Spencer, Nikos Koundouros, Joana B. Nunes, Sejeong Shin, Sang-Oh Yoon, Julie Han, Andre Chavez, Olivia M. Kester, Rabia Khan, Paul Zumbo, Eric E. Gardner, Bobak Parang, , John Blenis
This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.
bioRxiv · Sep 22, 2025 · PreprintCell Biology