Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration
Michelle Westerhoff, Nahal Brocke‐Ahmadinejad, Yulia Schaumkessel, Karl Köhrer, Arif Dönmez, Roohallah Ghodrat, Andrea Borchardt, Lluís Enjuanes-Ruiz, Julia Tigges, Katharina Koch, Gerhard Fritz, Arun Kumar Kondadi, Andreas S. Reichert
This study shows that low-dose doxorubicin treatment of human iPSCs causes mitochondrial dysfunction and transcriptional changes that impair cardiac regeneration in derived cardiomyocytes.
bioRxiv · Apr 18, 2025 · PreprintCell Biology