Katharina Koch

This study introduces a tunable laminar perfusion system for vasculature-on-chip to study sustained flow effects on vascular remodeling and immune interactions.

ToxCastLite provides a portable semantic evidence system linking in vitro bioactivity, in vivo toxicity, and exposure context for toxicology research.

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

This study shows that low-dose doxorubicin treatment of human iPSCs causes mitochondrial dysfunction and transcriptional changes that impair cardiac regeneration in derived cardiomyocytes.

The paper characterizes different BrainSphere models for neurotoxicity testing using microelectrode arrays, finding that media choice affects differentiation patterns and functional activity.