The Ccr4-Not complex monitors the translating ribosome for codon optimality
Robert Buschauer, Yoshitaka Matsuo, Takato Sugiyama, Ying-Hsin Chen, Najwa Alhusaini, Thomas J. Sweet, Ken Ikeuchi, Jingdong Cheng, Yasuko Matsuki, Risa Nobuta, Andrea Gilmozzi, Otto Berninghausen, Petr Těšina, Thomas A. Becker, Jeff M. Coller, , Roland Beckmann
The paper shows the Ccr4-Not complex interacts with the ribosome's E-site when codon optimality is low, linking translation efficiency to mRNA stability.
Science · Apr 16, 2020Peer-reviewedMolecular Biology