Michael A. Witting

This study shows that MTRR-1 regulates heterochromatin through mitochondrial homeostasis, not methionine synthesis, in C. elegans.

This study uses an oral protein tolerance test combined with metabolomics to show that sarcopenic older adults have slower postprandial decline in essential amino acids compared to young controls, suggesting altered anabolic sensitivity.

LipiDetective is a transformer model that accurately identifies molecular lipid species in tandem mass spectra using learned fragmentation patterns, improving comparability across experiments.

This study identifies miR-940 as a negative regulator of ferroptosis, showing it suppresses cell death by modulating key genes and GPX4 levels in cancer cells.

The paper identifies sphingolipids from a bacterial PKS as mediators of microbiota protection against pathogens in C. elegans.

This study shows that loss of SIN-3 in C. elegans disrupts mitochondrial function and metabolism, leading to mitochondrial fragmentation and altered metabolic flux.

COSMIC assigns confidence to structural annotations from mass spectra by combining database generation, in silico annotation, and a confidence score, outperforming existing methods and annotating novel structures.

The paper introduces FBMN, a method for improving molecular networking by enhancing quantitative analysis and isomer distinction using feature detection and alignment tools in the GNPS platform.

The paper develops iTAG-RNA to tag RNA in vivo, identifies hepatocyte-specific responses to dietary challenges, and demonstrates liver-to-adipose RNA transfer.