Reprogramming human T cell function and specificity with non-viral genome targeting
Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, Julia C. Carnevale, P. Jonathan Li, Joseph B Hiatt, Justin D. Saco, Paige E. Krystofinski, Han Li, Victoria R. Tobin, David N. Nguyen, Michael R. Lee, Amy L. Putnam, Andrea L. Ferris, , Alexander Marson
This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.
Nature · Jul 1, 2018Peer-reviewedGenetics