A moonlighting serpin of Tannerella forsythia compromises the bactericidal activity of neutrophils
Savannah C Morris, Florian Veillard, Danuta Mizgalska, Mariusz Madej, Małgorzata Benedyk‐Machaczka, Justyna Folkert, Barbara Aleksandra Potempa, Andrew Fuchs, Jan Potempa, Juhi Bagaitkar
This study identifies miropin, a prokaryotic serpin from Tannerella forsythia, which suppresses neutrophil antimicrobial activity by inhibiting serine proteases and myeloperoxidase, promoting bacterial survival in vivo.
bioRxiv · Oct 9, 2026 · PreprintImmunology