Juhi Bagaitkar

This study identifies miropin, a prokaryotic serpin from Tannerella forsythia, which suppresses neutrophil antimicrobial activity by inhibiting serine proteases and myeloperoxidase, promoting bacterial survival in vivo.

This study shows that Nox2 oxidase regulates neutrophilic inflammation in the oral cavity through Nrf2-dependent mechanisms, independent of its antimicrobial role.

This study shows that tyrosine phosphorylation regulates the coupling between one carbon metabolism and virulence in Porphyromonas gingivalis by controlling gingipain protease localization and activity.

This study shows that Tannerella forsythia's miropin inhibits Porphyromonas gingivalis proteases, reducing its virulence and challenging Tf's role as a pathogen.

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

This paper shows that Porphyromonas gingivalis proteases reduce viral load and modulate host interferon responses during RSV infection.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.