Resurrecting essential amino acid biosynthesis in a mammalian cell
Julie Trolle, Ross M. McBee, Andrew Kaufman, Sudarshan Pinglay, Henri Berger, Sergei V. German, Liyuan Liu, Michael J. Shen, Xinyi Guo, James A. Martin, Michael E. Pacold, Drew R. Jones, Jef D. Boeke, Harris H. Wang
This paper demonstrates the successful restoration of valine biosynthesis in mammalian cells by integrating synthetic pathways from E. coli, showing that ancient metabolic pathways can be reactivated in metazoans.
eLife · Sep 27, 2022Peer-reviewedSynthetic Biology