Author

Julie Trolle

NYU Langone HealthORCID 0000-0002-2497-3531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Drew R. JonesiD· 2 shared Jef D. BoekeiD· 2 shared Sudarshan PinglayiD· 2 shared Andrew Kaufman· 1 shared David FenyöiD· 1 shared Harris H. WangiD· 1 shared Henri Berger· 1 shared James A. MartiniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSynthetic Biology

Drew R. JonesORCID

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2 papers

Recent·Most cited

A shotgun approach for highly multiplexed mammalian metabolic engineering

Julie Trolle, Sara Sessa, Tori C. Rodrick, Drew R. Jones, David Fenyö, Sudarshan Pinglay, Jef D. Boeke

This paper introduces SGE, a method for screening metabolic pathways in mammalian cells, and finds that mitochondrial localization and large synthetic DNA constructs are key for successful pathway engineering.

bioRxiv · Jul 8, 2025 · PreprintSynthetic Biology

Resurrecting essential amino acid biosynthesis in a mammalian cell

Julie Trolle, Ross M. McBee, Andrew Kaufman, Sudarshan Pinglay, Henri Berger, Sergei V. German, Liyuan Liu, Michael J. Shen, Xinyi Guo, James A. Martin, Michael E. Pacold, Drew R. Jones, Jef D. Boeke, Harris H. Wang

This paper demonstrates the successful restoration of valine biosynthesis in mammalian cells by integrating synthetic pathways from E. coli, showing that ancient metabolic pathways can be reactivated in metazoans.

eLife · Sep 27, 2022Peer-reviewedSynthetic Biology