Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease
Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hye Min Kim, Jennifer P Wang, Megan L. Mair, Alma M. Perez, María de Haro, Huilan Wang, Ying‐Wooi Wan, Genevera I. Allen, Boxun Lu, Ismael Al‐Ramahi, Zhandong Liu, Juan Botas
The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.
bioRxiv · Nov 3, 2020 · PreprintSystems Biology