Jennifer P Wang

CRISPR editing of candidate host factors that impact influenza A virus infection

This paper uses CRISPR to test host factors affecting influenza A virus infection, finding that CMAS knockout and B4GALNT2 overexpression restrict IAV, while ADAR1 overexpression has a pro-viral effect on CVB.

Tissue and cell-type specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models

This study identifies molecular and functional changes in mouse and human models of 16p11.2 reciprocal genomic disorder, revealing context-specific disruptions in energy metabolism, RNA processing, and neuronal development.

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.

N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells

This study shows n-3 PUFAs promote astrocyte differentiation and increase neurotrophin production in patient-derived neural stem cells, independent of cAMP and dependent on CREB.

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults

The paper uses single-cell RNA sequencing to study influenza infection in human nasal washes, identifying a novel goblet cell population and tracking viral variation across infected individuals.

Increased microglial synapse elimination in patient-specific models of schizophrenia

The paper shows increased microglial synapse elimination in schizophrenia patient models and links it to genetic variants and potential therapeutic interventions.