Author

Megan L. Mair

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Juan BotasiD· 3 shared Alma M. PereziD· 1 shared Andrew Laitman· 1 shared Boxun LuiD· 1 shared Christian NériiD· 1 shared Cloé Mendoza· 1 shared Emmanuel BrouilletiD· 1 shared Francesca FarinaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Juan BotasORCID

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Author profile →

4 papers

Recent·Most cited

Modeling Huntington disease against age-related genes reveals CXXC4 as an epigenetic target to restore DRD1 striatal neuron activity

M. Arrieta, Francesca Farina, Tamara Monteagudo Aboy, Megan L. Mair, Cloé Mendoza, Huy Tran, Jeff Aaronson, Jim Rosinski, Lisa Ellerby, Emmanuel Brouillet, Jean‐Michel Peyrin, Juan Botas, Christian Néri, Lucile Mégret

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

bioRxiv · Jan 13, 2026 · PreprintNeuroscience

Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures

Joshua L Justice, Todd M. Greco, Josiah E. Hutton, Tavis J. Reed, Megan L. Mair, Juan Botas, Ileana M. Cristea

The paper identifies striatum-selective molecular interactions of huntingtin using multi-epitope assays and models, revealing its role in transcriptional regulation and disease mechanisms.

Molecular Systems Biology · Apr 1, 2025Peer-reviewedNeuroscience

Network topology and evolution of the gene co-expression of T-cells during immuno-senescence

Megan L. Mair, Nicolas Tchitcheck, Tarynn M. Witten, Véronique Thomas‐Vaslin

The paper analyzes gene co-expression network structures in young and old mice T-cells to show aging-related changes in network organization and transcriptional regulation.

bioRxiv · Sep 1, 2021 · PreprintSystems Biology

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hye Min Kim, Jennifer P Wang, Megan L. Mair, Alma M. Perez, María de Haro, Huilan Wang, Ying‐Wooi Wan, Genevera I. Allen, Boxun Lu, Ismael Al‐Ramahi, Zhandong Liu, Juan Botas

The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.

bioRxiv · Nov 3, 2020 · PreprintSystems Biology