Clostridioides difficile stimulates CCL20 expression in human colonoid monolayers in a transwell-based co-culture system that supports its anaerobic growth
Paola Zucchi, Adrianne D. Gladden, Andrew W. Day, Jules M. Dressler, Revathi Govind, Mohammad Almeqdadi, Jatin Roper, A.T. Tai, Rebecca Batorsky, Carol A. Kumamoto
This study develops a co-culture system to study C. difficile interaction with human intestinal epithelium and finds CCL20 expression is upregulated in response to the bacterium.
International Journal of Microbiology · Jan 1, 2026Peer-reviewedMicrobiology