Single-molecule imaging reveals the interplay between transcription factors, nucleosomes, and transcriptional bursting
Benjamin T. Donovan, Anh Huynh, David A. Ball, Heta Patel, Michael Guy Poirier, Daniel R. Larson, Matthew Ferguson, Tineke Laura Lenstra
This study uses single-molecule imaging to show that Gal4 dwell time determines transcriptional burst size in yeast, with nucleosomes reducing dwell time and affecting transcriptional bursting kinetics.
The EMBO Journal · May 17, 2019Peer-reviewedMolecular Biology