Heta Patel

The paper shows DNA supercoiling inhibits transcriptional bursting of neighboring genes in yeast, differing from bacterial mechanisms.

This study investigates how TF clustering affects gene expression by analyzing Gal4 in budding yeast, finding that clustering aids target search but does not contribute to activation.

The paper shows that transcriptional regulation in yeast is cyclic and irreversible, violating thermodynamic equilibrium.

The paper identifies Hda1C as a repressor of divergent non-coding RNA transcription in budding yeast by reducing transcription initiation frequency and histone acetylation.

This study uses single-molecule imaging to show that Gal4 dwell time determines transcriptional burst size in yeast, with nucleosomes reducing dwell time and affecting transcriptional bursting kinetics.