TopBP1 utilises a bipartite GINS binding mode to support genome replication
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida‐Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sánchez‐García, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.
Nature Communications · Feb 27, 2024Peer-reviewedMolecular Biology