Yasser Almeida‐Hernández

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.