Elsa Sánchez‐García

Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

MTBP allosterically activates Cdk8-CycC kinase activity

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

TopBP1 utilises a bipartite GINS binding mode to support genome replication

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential

The paper investigates how EPI-X4 binds to CXCR4 using simulations and experiments, leading to the design of more potent and safer CXCR4 antagonists.