Irene Mei

This study shows Samp1 is essential for myogenic differentiation by linking its role in chromatin organization at the nuclear periphery to the transcriptional program of muscle development.

This study investigates the role of beta2-microglobulin and HLA in motor neuron vulnerability in ALS, finding dynamic regulation but not major disease modification.

The paper develops a linear regression model to predict biological brain ageing and identifies age-related gene expression patterns linked to Parkinson's disease susceptibility.

This study uses single-cell RNA sequencing to identify shared mitochondrial dysfunction in motor neurons across FUS and TARDBP ALS mutations, suggesting common toxic mechanisms.

This paper describes a protocol to generate human posterior axial assembloids from pluripotent stem cells, demonstrating multi-lineage differentiation and tissue complexity.

The paper identifies gene expression patterns in motor neurons that predict ALS across species and SOD1 mutations, revealing differences in vulnerability and resilience.

The paper analyzes single-nucleus RNA-seq data from human spinal cord neurons, identifies motor neurons as rare, and highlights discrepancies with a prior study due to potential misclassification of cholinergic debris.

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.