Discovery of a Cell-Permeable Gi-Signaling Inhibitor
Amira Naimi, Tim Berger, Philipp Dahlhaus, Marcel Rossol, Jonas Mühle, Wieland Steinchen, Gert Bange, Uwe Linne, Paolo Stincone, Xavier Deupí, Gebhard F. X. Schertler, Lars Jürgenliemke, Evi Kostenis, Jens Kockskämper, Daniel Hilger, , Raphael Reher
This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.
bioRxiv · Aug 4, 2026 · PreprintBiochemistry