Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency
Yanan Zhu, Alex B. Kleinpeter, Juan S. Rey, Juan Shen, Yao Shen, Jialu Xu, Nathan J. Hardenbrook, Long Chen, Anka Lucic, Juan R. Perilla, Eric O. Freed, Peijun Zhang
This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.
bioRxiv · Feb 9, 2025 · PreprintMicrobiology