Nathan J. Hardenbrook

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

This study identifies galactosyrin, an iminosugar produced by Pseudomonas syringae, which inhibits plant β-galactosidase and alters host glycobiology to aid infection.

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.

Cryo-ET of 169 nm β-carboxysomes from low-light Synechococcus elongatus reveals ~639 Rubiscos in concentric layers with CcmM bound at RbcL grooves; QconCAT proteomics yields the complete absolute protein stoichiometry.