Yao Shen

In-cell structural analysis reveals a distinctive chloroplast ribosome in Chlamydomonas reinhardtii

The paper determines the structure of native chloroplast ribosomes in Chlamydomonas reinhardtii and identifies lineage-specific extensions linked to ribosome dynamics and evolution.

Structural diversification of phage tail fibres enables recognition of diverse type IV pili

The paper shows how phage tail fibre structure determines their ability to recognize diverse type IV pils despite receptor variation.

In situ chromatin dynamics and HIV-1 nuclear trafficking

This study visualizes chromatin structure and HIV-1 nuclear trafficking in situ, showing HIV-1 cores preferentially associate with open chromatin and are excluded from compact regions.

Correlative In Situ Cryo-ET Reveals Cellular and Viral Remodeling Associated with Selective HIV-1 Core Nuclear Import

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity

This study shows that an ordered mature MA lattice is not required for HIV-1 infectivity, as a triple mutant lacking this structure remains infectious.

Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.