Long Chen

The paper maps thylakoid membrane biogenesis in Chlamydomonas reinhardtii using integrated imaging and proteomics, revealing decentralized synthesis and hierarchical assembly of photosynthetic complexes.

This study visualizes chromatin structure and HIV-1 nuclear trafficking in situ, showing HIV-1 cores preferentially associate with open chromatin and are excluded from compact regions.

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

This study shows that an ordered mature MA lattice is not required for HIV-1 infectivity, as a triple mutant lacking this structure remains infectious.

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.