Author

Saroor A. Patel

Imperial College LondonORCID 0000-0002-6331-1557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alice R. Rothwell· 1 shared Amandine EverardiD· 1 shared Ana Luísa NevesiD· 1 shared Anna C. ObenaufiD· 1 shared Anna Dyas· 1 shared Antonis MyridakisiD· 1 shared Blerina Ahmetaj‐ShalaiD· 1 shared Christelle Gérard· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Alice R. Rothwell

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2 papers

Recent·Most cited

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

Jianfeng Ge, Shoko Hirosue, Leticia Castillon, Saroor A. Patel, Ludovic Wesolowski, Anna Dyas, Cissy Yong, Sanne de Haan, Jarno Drost, Grant Duncan Stewart, Anna C. Obenauf, Daniel Muñoz‐Espín, Sakari Vanharanta

This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.

EMBO Molecular Medicine · Dec 19, 2025Peer-reviewedCancer Biology

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

Julien Chilloux, François Brial, Amandine Everard, David R. Smyth, Petros Andrikopoulos, Liyong Zhang, Hubert Plovier, Antonis Myridakis, Lesley Hoyles, José María Moreno‐Navarrete, Jèssica Latorre, Viviana Casagrande, Rossella Menghini, Blerina Ahmetaj‐Shala, Christine Blancher, , Marc‐Emmanuel Dumas

This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.

Nature Metabolism · Dec 8, 2025Peer-reviewedPhysiology