Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: Insights from in vitro assays
Miriam Kelm, Nourhan Nasr, Sonja Bendig, Dieter Kabelitz, Marta Lustig, Heiko Trautmann, Anna Laqua, Christian Peters, Daniela Wesch, Hans‐Heinrich Oberg, Ottmar Janßen, Thomas Valerius, Claudia Dorothea Baldus, Alexander Scheffold, Monika Brüggemann, Guranda Chitadze
This study evaluates BLN-driven cytotoxicity in β and γδ T-cell subsets, finding β T cells show superior cytotoxicity while γδ T cells exhibit stable effector-memory states and reduced susceptibility to activation-induced cell death.
Frontiers in Immunology · Feb 6, 2026Peer-reviewedImmunology