Ultrasensitive capture of human herpes simplex virus genomes directly from clinical samples reveals extraordinarily limited evolution in cell culture
Alexander L. Greninger, Pavitra Roychoudhury, Hong Jian Xie, Amanda M. Casto, Anne Cent, Gregory Pepper, David M. Koelle, Meei-Li W. Huang, Anna Wald, Christine Johnston, Keith R. Jerome
The paper develops tools to directly sequence HSV genomes from clinical samples with high sensitivity and low viral load, revealing limited evolution during cell culture.
mSphere · Jun 12, 2018Peer-reviewedGenomics