Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons
Subrata Pradhan, Keegan M. Bush, Nan Zhang, RAJ KUMAR PANDITA, Chi-Lin Tsai, Charlene Smith-Geater, Devon F. Pandlebury, Sagar Gaikwad, Francis Leonard, Linghui Nie, Annie Tao, William K. Russell, Subo Yuan, Sanjeev Choudhary, Kenneth S. Ramos, , Partha S. Sarkar
This study identifies a mechanism where HTT recruits BRG1 and NHEJ components to repair transcription-associated DSBs in neurons, and shows that mutant HTT impairs this process, contributing to HD pathology.
bioRxiv · Sep 19, 2024 · PreprintNeuroscience