Fc-dependent protective efficacy of non-inhibitory antibodies targeting influenza A virus neuraminidase is limited by epitope availability
Mirte N. Pascha, Marlies Ballegeer, Rien van Haperen, Annick C. Kooij, Danique M. van Miltenburg, Anthony A. Smits, Jelle G. Schipper, Hongrui Cui, Irina C. Albulescu, Berend‐Jan Bosch, Frank G. Grosveld, Frank J. M. van Kuppeveld, Xavier Saelens, Dubravka Drabek, Cornelis A. M. de Haan
This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.
bioRxiv · Sep 3, 2024 · PreprintMicrobiology