Berend‐Jan Bosch

Spike and host glycan determinants of HKU1 airway tropism

This study identifies spike and host glycan determinants of HKU1 airway tropism by showing preferential binding to 9-O-acetylated 2,8-linked disialosides and structural insights into ligand recognition.

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity

This study presents cryo-EM structures of cetacean coronavirus S proteins, revealing unique structural features and glycosylation patterns that highlight structural plasticity and host adaptation.

Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin 1

This study determines the structure of SARS-CoV-2 spike in complex with contactin 1 and quantifies their interaction, revealing new insights into viral neurotropism.

The gH/gL/gO Complex of Elephant Endotheliotropic Herpesvirus 1A Functions as a Receptor Binding Complex

This paper determines the structure of the EEHV1A gH/gL/gO complex and shows it functions as the receptor-binding complex for EEHV1A.

A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity

This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.

Fc-dependent protective efficacy of non-inhibitory antibodies targeting influenza A virus neuraminidase is limited by epitope availability

This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.